The role of tumor stem cells in the development of drug resistance of melanoma

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Abstract

Despite the fact that melanoma is a tumor of visual localization, mortality from skin melanoma remains one of the leading causes of mortality worldwide. Early metastasis of melanoma, even during the initial stages of the tumor process, indicates a high malignant potential of the tumor. Moreover, metastatic melanoma is resistant to current chemotherapy regimens, which is a significant problem today. Progression, resistance to drug therapy of skin melanoma is associated with a population of tumor stem cells, which are characterized by dysregulation of signaling pathways and aberrant phenotypes. The formation of tumor stem cells contributes to their microenvironment. Surface markers expressed by tumor stem cells include transporter proteins that mediate chemoresistance. The study of the microenvironment, the activity of the expressed antigenic determinants makes it possible to understand the processes of chemoresistance formation and to discover (develop) strategies for its overcoming. The article provides an analysis of the literature data on the significance of tumor stem cells in the development of drug resistance of melanoma.

About the authors

S. V. Chulkova

N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Hearth of Russia; N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia.

Author for correspondence.
Email: chulkova@mail.ru
ORCID iD: 0000-0003-4412-5019
24 Kashyrskoe Sh., Moscow 115478; 1 Ostrovitianov St., Moscow 117997. Russian Federation

I. G. Markina

N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Hearth of Russia.

24 Kashyrskoe Sh., Moscow 115478. Russian Federation

O. A. Chernysheva

N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Hearth of Russia.

24 Kashyrskoe Sh., Moscow 115478. Russian Federation

N. V. Grishchenko

N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Hearth of Russia.

ORCID iD: 0000-0002-7515-8182
24 Kashyrskoe Sh., Moscow 115478. Russian Federation

A. S. Antipova

N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Hearth of Russia.

24 Kashyrskoe Sh., Moscow 115478. Russian Federation

K. C. Titov

A. S. Loginоv Moscow Clinical Scientific Center.

ORCID iD: 0000-0003-4460-9136
86 Shosse Entuziastov, Moscow 111123. Russian Federation

D. A. Ryabchikov

N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Hearth of Russia.

24 Kashyrskoe Sh., Moscow 115478. Russian Federation

A. V. Egorova

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia.

1 Ostrovitianov St., Moscow 117997. Russian Federation

D. R. Naskhletashvili

N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Hearth of Russia.

24 Kashyrskoe Sh., Moscow 115478. Russian Federation

N. N. Tupitsyn

N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Hearth of Russia.

ORCID iD: 0000-0003-3966-128X
24 Kashyrskoe Sh., Moscow 115478. Russian Federation

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