Email this article Indolocarbazole derivatives – a promising class of anticancer drugs
- Authors: Kiseleva M.P.1, Pokrovsky V.S.1,2, Tataskiy V.V.1, Borisova L.M.1, Golubeva I.S.1, Ektova L.V.1
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Affiliations:
- N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
- RUDN University
- Issue: Vol 17, No 4 (2018)
- Pages: 20-26
- Section: REVIEWS
- Published: 11.12.2018
- URL: https://bioterapevt.abvpress.ru/jour/article/view/1121
- DOI: https://doi.org/10.17650/1726-9784-2018-17-4-20-26
- ID: 1121
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Abstract
The paper discusses the possible mechanisms of antitumor action of indolocarbazole derivatives. Here we present a data that show interaction drugs based on indolocarbazole derivatives with several intracellular targets and consequently activation different pathways of cell death. Also we present results of our studies on the mechanisms of antitumor action of compounds LCS-1006 and LCS-1208 synthesized in the N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia.
About the authors
M. P. Kiseleva
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Author for correspondence.
Email: marina-kiselyova@mail.ru
24 Kashirskoe Shosse, Moscow 115478 Russian Federation
V. S. Pokrovsky
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; RUDN University
ORCID iD: 0000-0003-4006-9320
24 Kashirskoe Shosse, Moscow 115478
6 Miklukho-Maklaya St., Moscow 117198
Russian FederationV. V. Tataskiy
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia24 Kashirskoe Shosse, Moscow 115478 Russian Federation
L. M. Borisova
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia24 Kashirskoe Shosse, Moscow 115478 Russian Federation
I. S. Golubeva
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia24 Kashirskoe Shosse, Moscow 115478 Russian Federation
L. V. Ektova
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia24 Kashirskoe Shosse, Moscow 115478 Russian Federation
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