Oncolitical viruses in the therapy of malignant neoplastic diseases

N. K. Klaan; Клаан Н. К.; L. P. Аkin’shina; Акиньшина Л. П.; T. A. Pronina; Пронина Т. А.

doi:10.17650/1726-9784-2018-17-4-6-19

Oncolitical viruses in the therapy of malignant neoplastic diseases

Authors: Klaan N.K.¹, Аkin’shina L.P.¹, Pronina T.A.¹
Affiliations:
1. All-Russian Institute Scientific and Technical Information
Issue: Vol 17, No 4 (2018)
Pages: 6-19
Section: REVIEWS
Published: 11.12.2018
URL: https://bioterapevt.abvpress.ru/jour/article/view/1120
DOI: https://doi.org/10.17650/1726-9784-2018-17-4-6-19
ID: 1120

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Abstract

The main types of oncolytic viruses and the mechanisms of their action on the tumor cells are described in this review. Examples of optimization of the viral genome are given with a view to enhancing the oncolytic properties of the virus. The achievements in the field of development of antitumour agents based on oncolytic viruses and methods of their application in oncology are described.